INSYN1-AS1

Across TCGA pan-cancer cohorts, INSYN1-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated INSYN1-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher INSYN1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INSYN1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

BLCA, THCA, and LGG are the cancer types where INSYN1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	IV	0.433	0.674	.001	74	view →
THCA	DFS	Tertile	All	0.574	0.891	<.001	51	view →
LGG	OS	Median	All	0.523	0.344	<.001	51	view →
UVM	OS	Tertile	III,IV	0.529	1.000	.005	49	view →
UCS	DFS	Median	III,IV	0.522	0.147	.003	46	view →
UCEC	DFS	Quartile	All	0.757	0.876	<.001	34	view →
OV	OS	Tertile	III,IV	0.741	0.659	.013	18	view →
HNSC	OS	Tertile	All	0.580	0.686	.014	18	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	16	view →
CESC	OS	Tertile	IV	0.956	0.454	.047	12	view →
ACC	OS	Median	All	0.794	0.939	.016	9	view →
PAAD	OS	Median	All	0.497	0.327	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

INSYN1-AS1–BLCA (OS)

Open the BLCA breakdown →