INSYN1-AS1

Across TCGA pan-cancer cohorts, INSYN1-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of INSYN1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where INSYN1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types INSYN1-AS1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where INSYN1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INSYN1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−1.756	<.001	12	view →
KIRP	Male	All	−1.747	<.001	11	view →
KICH	All	All	+1.889	<.001	6	view →
UCEC	All	All	−1.013	<.001	6	view →
BRCA	All	All	+0.213	<.001	6	view →
READ	All	All	−0.055	<.001	5	view →
THCA	All	II,III,IV	−0.036	.002	5	view →
LUSC	All	All	+0.385	<.001	3	view →
STAD	Female	All	−0.171	.034	3	view →
PRAD	All	All	−0.342	<.001	2	view →
ESCA	Female	All	−0.070	.035	1	view →
LIHC	Female	II,III,IV	+0.028	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

INSYN1-AS1–KIRC

Open the KIRC breakdown →