INSRR

Across TCGA patient cohorts, INSRR mutation is significantly associated with the RNA expression of many other genes, with 4,838 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSRR-associated genes across cancer lineages are KIF23, RCC1, and DTL. Each is linked with INSRR in more than 3 cancer types. Because this analysis shows association rather than direction, both INSRR-to-partner and partner-to-INSRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by INSRR-low versus INSRR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSRR→partner) and Y-score (partner→INSRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KIF23 →	+0.464	+2.605	.003	.005	3	4
COAD	RCC1 →	+0.512	+2.960	<.001	<.001	3	4
UCEC	DTL →	+0.481	+1.765	<.001	<.001	3	4
SKCM	MCM2 →	+0.367	+1.186	.008	.004	3	4
UCEC	FEN1 →	+0.481	+1.847	<.001	<.001	3	4
UCEC	CD207 →	-0.541	-1.211	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,838 associations by consensus.

KIF23 by INSRR expression — COAD

Explore this box plot interactively →