INSM1

Across TCGA patient cohorts, INSM1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSM1-associated genes across cancer lineages are GAPDH, Heregulin, and JNK2. Each is linked with INSM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSM1-to-partner and partner-to-INSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by INSM1-low versus INSM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSM1→partner) and Y-score (partner→INSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.705	+3.321	.004	.010	3	2
UCEC	Heregulin →	-0.158	-2.321	.006	.034	3	1
UCEC	JNK2 →	+0.190	+3.009	.040	.019	3	1
UCEC	MEK1 →	+0.364	+3.000	.032	.036	3	1
UCEC	p70-S6K_pT389 →	-0.260	-3.169	.003	.018	3	1
UCEC	P-Cadherin →	-0.161	-3.169	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GAPDH by INSM1 expression — UCEC

Explore this box plot interactively →