INSM1

Across TCGA pan-cancer cohorts, INSM1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of INSM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where INSM1 RNA is repressed in tumor relative to normal tissue. In most cancer types INSM1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, BRCA, and COAD are the cancer types where INSM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INSM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.104	<.001	7	view →
BRCA	All	II,III,IV	+0.921	<.001	6	view →
COAD	Male	All	−0.853	.007	6	view →
READ	All	All	−1.737	<.001	5	view →
PRAD	All	All	+1.339	<.001	2	view →
LUSC	All	All	+0.686	.004	2	view →
THCA	All	All	−0.117	.009	2	view →
THCA	All	IV	+0.069	.006	2	view →
STAD	Male	IV	−1.260	.011	1	view →
ESCA	Female	All	−1.153	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

INSM1–KICH

Open the KICH breakdown →