INSM1

Across TCGA cell cohorts, INSM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,383 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible INSM1-associated GO terms across cancer lineages are Noradrenergic neuron development, Neuroendocrine cell differentiation, and Detoxification of copper ion. Each is linked with INSM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both INSM1-to-partner and partner-to-INSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Noradrenergic neuron development grouped by INSM1-low versus INSM1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSM1→partner) and Y-score (partner→INSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Noradrenergic neuron development →	+1.105	+3.446	<.001	<.001	3	14
OESOPHAGUS	Neuroendocrine cell differentiation →	-0.289	-0.133	.001	.008	3	9
BLOOD_Lymphoma	Detoxification of copper ion →	-0.176	-0.594	<.001	.004	3	6
BLOOD_Lymphoma	Stress response to copper ion →	-0.176	-0.594	<.001	.004	3	6
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.062	+0.597	.002	.003	3	6
SOFT_TISSUE	Toll-like receptor 2 signaling pathway →	-0.144	-0.808	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,383 associations by consensus.

Noradrenergic neuron development by INSM1 expression — LUNG_SCLC

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