INSM1

Across TCGA cell cohorts, INSM1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INSM1-associated genes across cancer lineages are USP17L15, BPIFA2, and GML. Each is linked with INSM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSM1-to-partner and partner-to-INSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L15 grouped by INSM1-low versus INSM1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSM1→partner) and Y-score (partner→INSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	USP17L15 →	+0.013	+4.807	<.001	.006	3	2
BLOOD_Myeloma	BPIFA2 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1G1 →	+0.083	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

USP17L15 by INSM1 expression — BLOOD_Myeloma

Explore this box plot interactively →