INSL5

Across TCGA patient cohorts, INSL5 mutation is significantly associated with the RNA expression of many other genes, with 245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSL5-associated genes across cancer lineages are UBE2V1P4, TP53TG3F, and LYZL1. Each is linked with INSL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSL5-to-partner and partner-to-INSL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V1P4 grouped by INSL5-low versus INSL5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL5→partner) and Y-score (partner→INSL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2V1P4 →	+0.148	+5.103	<.001	.008	3	2
BRCA	TP53TG3F →	+0.014	+9.057	<.001	.003	3	1
CESC	LYZL1 →	+0.049	+5.418	<.001	.005	3	1
CESC	RNA5SP447 →	+0.359	+5.201	.003	.007	3	1
CESC	MIR30B →	+0.418	+5.010	<.001	.009	3	1
CESC	RN7SKP213 →	+0.307	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

UBE2V1P4 by INSL5 expression — CESC

Explore this box plot interactively →