INSL5

Across TCGA pan-cancer cohorts, INSL5 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated INSL5 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher INSL5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INSL5 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

KICH, LGG, and PAAD are the cancer types where INSL5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.794	0.986	<.001	78	view →
LGG	DFS	Median	All	0.655	0.814	<.001	46	view →
PAAD	OS	Median	All	0.546	0.265	<.001	39	view →
KIRC	DFS	Quartile	All	0.731	0.822	.008	39	view →
ACC	OS	Median	All	0.960	0.677	<.001	28	view →
CESC	OS	Tertile	All	0.925	0.847	.017	22	view →
LUAD	DFS	Quartile	IV	0.107	0.698	<.001	18	view →
THCA	DFS	Median	II,III,IV	0.828	0.633	.018	16	view →
READ	DFS	Tertile	IV	0.719	0.374	.022	15	view →
UCS	OS	Tertile	IV	0.224	0.653	.047	12	view →
LIHC	OS	Tertile	III,IV	0.336	0.643	.007	9	view →
CHOL	DFS	Tertile	IV	0.950	0.406	.040	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

INSL5–KICH (OS)

Open the KICH breakdown →