INSL3

Across TCGA patient cohorts, INSL3 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible INSL3-associated genes across cancer lineages are OR5L1, RN7SKP8, and RNU6-1217P. Each is linked with INSL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSL3-to-partner and partner-to-INSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5L1 grouped by INSL3-low versus INSL3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL3→partner) and Y-score (partner→INSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5L1 →	+0.044	+7.731	<.001	.009	3	1
SKCM	RN7SKP8 →	+0.168	+5.594	<.001	.004	3	1
SKCM	RNU6-1217P →	+0.367	+5.867	<.001	.003	3	1
SKCM	LINC00307 →	+0.100	+5.097	<.001	.008	3	1
BRCA	RNU4ATAC3P →	+0.315	+7.731	<.001	.009	3	1
BRCA	RNA5SP472 →	+0.332	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR5L1 by INSL3 expression — BRCA

Explore this box plot interactively →