INS

Across TCGA patient cohorts, INS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,440 significant associations in total. STAD shows the largest number of these associations.

The most reproducible INS-associated GO terms across cancer lineages are Base-excision repair, Mitotic cytokinesis, and Mitochondrial RNA metabolic process. Each is linked with INS in more than 5 cancer types. Because this analysis shows association rather than direction, both INS-to-partner and partner-to-INS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Base-excision repair grouped by INS-low versus INS-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INS→partner) and Y-score (partner→INS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Base-excision repair →	+0.066	+0.020	<.001	.002	3	6
STAD	Mitotic cytokinesis →	+0.072	+0.040	<.001	<.001	3	5
STAD	Mitochondrial RNA metabolic process →	+0.067	+0.033	<.001	.002	3	5
STAD	Negative regulation of mRNA processing →	+0.079	+0.040	<.001	<.001	3	5
STAD	Positive regulation of binding →	+0.068	+0.037	<.001	<.001	3	5
STAD	Regulation of DNA binding →	+0.063	+0.035	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,440 associations by consensus.

Base-excision repair by INS expression — ESCA

Explore this box plot interactively →