INS

Across TCGA pan-cancer cohorts, INS RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated INS data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher INS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INS expression acts as an unfavorable survival marker, although some lineages such as OV and SKCM show a favorable association.

MESO, THCA, and THYM are the cancer types where INS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.288	0.608	<.001	114	view →
THCA	OS	Tertile	All	0.660	0.937	<.001	54	view →
THYM	OS	Tertile	All	0.798	1.000	<.001	48	view →
UCEC	DFS	Tertile	All	0.734	0.847	.021	36	view →
PRAD	DFS	Tertile	All	0.518	0.804	<.001	36	view →
SARC	OS	Tertile	All	0.642	0.902	<.001	36	view →
COAD	OS	Tertile	All	0.414	0.619	.011	30	view →
ESCA	OS	Tertile	II,III,IV	0.105	0.867	.016	30	view →
KIRC	DFS	Tertile	IV	0.187	0.541	.003	30	view →
CHOL	OS	Tertile	All	0.270	0.751	.008	18	view →
LUSC	DFS	Tertile	III,IV	0.157	0.779	.018	18	view →
ACC	DFS	Tertile	IV	0.050	0.405	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

INS–MESO (OS)

Open the MESO breakdown →