INS

Across TCGA patient cohorts, INS protein abundance is significantly associated with the RNA expression of many other genes, with 1,999 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible INS-associated genes across cancer lineages are PES1, SEZ6L, and LGALS1. Each is linked with INS in more than 1 cancer types. Because this analysis shows association rather than direction, both INS-to-partner and partner-to-INS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, INS versus PES1 in PDAC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INS→partner) and Y-score (partner→INS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PES1 →	-0.234	-0.486	.002	.002	3	1
PDAC	SEZ6L →	+0.708	+0.626	<.001	<.001	3	1
PDAC	LGALS1 →	-0.388	-0.479	.001	<.001	3	1
PDAC	HMOX1 →	-0.703	-0.630	.001	.001	3	1
PDAC	THOC5 →	-0.230	-0.439	.004	.008	3	1
PDAC	MCM5 →	-0.378	-0.515	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,999 associations by consensus.

INS vs PES1 — PDAC

Explore this scatter interactively →