INS

Across TCGA patient cohorts, INS mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INS-associated genes across cancer lineages are KRTAP23-1, RNA5SP502, and RNU6-495P. Each is linked with INS in more than 1 cancer types. Because this analysis shows association rather than direction, both INS-to-partner and partner-to-INS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP23-1 grouped by INS-low versus INS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INS→partner) and Y-score (partner→INS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRTAP23-1 →	+0.380	+3.717	<.001	.005	3	1
UCEC	RNA5SP502 →	+0.817	+3.993	.002	.001	3	1
UCEC	RNU6-495P →	+0.648	+3.599	<.001	.007	3	1
UCEC	RNU6-1066P →	+0.837	+3.717	<.001	.005	3	1
UCEC	SNORD116-10 →	+0.335	+4.335	<.001	.007	3	1
UCEC	RNU6-595P →	+0.718	+3.856	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

KRTAP23-1 by INS expression — UCEC

Explore this box plot interactively →