INPPL1

Across TCGA cell cohorts, INPPL1 mutation is significantly associated with the RNA expression of many other genes, with 669 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPPL1-associated genes across cancer lineages are KLK12, IFNA14, and MPPED1. Each is linked with INPPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both INPPL1-to-partner and partner-to-INPPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by INPPL1-low versus INPPL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPPL1→partner) and Y-score (partner→INPPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	2
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	2
LUNG_NSCLC_LUAD	MPPED1 →	+0.305	+3.736	<.001	.004	3	2
LARGE_INTESTINE	ANKRD17 →	+0.639	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	LARP1B →	+0.732	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	AGL →	+0.797	+3.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 669 associations by consensus.

KLK12 by INPPL1 expression — SOFT_TISSUE

Explore this box plot interactively →