INPP5K

Across TCGA pan-cancer cohorts, INPP5K mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated INPP5K data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher INPP5K mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated INPP5K expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where INPP5K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.821	0.445	.004	27	view →
CCRCC	DFS	Median	II,III,IV	0.747	0.483	.008	25	view →
PDAC	DFS	Median	All	0.878	0.706	.010	17	view →
UCEC	OS	Median	All	0.981	0.916	.038	6	view →
LUAD	DFS	Quartile	II,III,IV	0.653	0.941	.016	4	view →
GBM	OS	Median	All	0.447	0.596	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

INPP5K–HNSC (DFS)

Open the HNSC breakdown →