INPP5K

Across TCGA patient cohorts, INPP5K mutation is significantly associated with the RNA expression of many other genes, with 781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5K-associated genes across cancer lineages are RNU6-1082P, RNU6-392P, and RBM22P1. Each is linked with INPP5K in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5K-to-partner and partner-to-INPP5K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1082P grouped by INPP5K-low versus INPP5K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5K→partner) and Y-score (partner→INPP5K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1082P →	+0.231	+2.873	<.001	<.001	3	2
STAD	RNU6-392P →	+0.365	+5.105	<.001	.008	3	2
SKCM	RBM22P1 →	+0.253	+4.947	<.001	<.001	3	2
SKCM	RPS15AP25 →	+0.167	+4.310	<.001	.003	3	1
SKCM	MIR1270 →	+0.590	+4.243	.003	.003	3	1
SKCM	COX6B1P2 →	+0.188	+4.877	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 781 associations by consensus.

RNU6-1082P by INPP5K expression — UCEC

Explore this box plot interactively →