INPP5K

Across TCGA patient cohorts, INPP5K mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5K-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK_pT183_Y185, and MSH2. Each is linked with INPP5K in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5K-to-partner and partner-to-INPP5K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by INPP5K-low versus INPP5K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5K→partner) and Y-score (partner→INPP5K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.420	+1.807	.045	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.163	-2.000	.019	.030	3	1
UCEC	MSH2 →	-0.236	-2.295	.013	.033	3	1
UCEC	MSH6 →	-0.429	-2.000	.001	.029	3	1
UCEC	PDCD4 →	-0.547	-3.459	.004	.005	3	1
UCEC	Shc_pY317 →	-0.134	-2.459	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Acetyl-a-Tubulin-Lys40 by INPP5K expression — UCEC

Explore this box plot interactively →