INPP5E

Across TCGA pan-cancer cohorts, INPP5E mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP5E data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher INPP5E mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INPP5E expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where INPP5E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.391	0.803	<.001	17	view →
UCEC	DFS	Tertile	All	0.652	1.000	.042	12	view →
GBM	OS	Quartile	All	0.668	0.877	.022	6	view →
LSCC	DFS	Quartile	III,IV	0.980	0.206	.030	4	view →
CCRCC	DFS	Median	II,III,IV	0.278	0.876	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INPP5E–LUAD (OS)

Open the LUAD breakdown →