INPP5E

Across TCGA pan-cancer cohorts, INPP5E RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of INPP5E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where INPP5E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INPP5E is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where INPP5E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP5E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.165	<.001	11	view →
HNSC	Male	IV	+1.109	<.001	10	view →
LIHC	Female	II,III,IV	+1.079	<.001	8	view →
STAD	Male	II,III,IV	+1.103	<.001	6	view →
CHOL	All	All	+1.933	<.001	5	view →
READ	All	All	+0.785	<.001	5	view →
BLCA	All	All	+0.542	.007	5	view →
KIRP	All	IV	+0.995	.010	4	view →
ESCA	All	All	+0.783	.010	4	view →
UCEC	All	All	−0.524	.012	4	view →
KIRC	Female	All	+0.454	<.001	2	view →
BRCA	Female	All	−0.199	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

INPP5E–COAD

Open the COAD breakdown →