INPP5E

Across TCGA patient cohorts, INPP5E mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. COAD shows the largest number of these associations.

The most reproducible INPP5E-associated genes across cancer lineages are DC, Macrophages, and Adipocytes. Each is linked with INPP5E in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5E-to-partner and partner-to-INPP5E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DC grouped by INPP5E-low versus INPP5E-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5E→partner) and Y-score (partner→INPP5E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DC →	+0.018	+2.833	.034	.014	3	1
COAD	Macrophages →	+0.024	+4.288	.004	<.001	3	1
UCEC	Adipocytes →	+0.023	+2.507	.026	.022	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DC by INPP5E expression — COAD

Explore this box plot interactively →