INPP5E

Across TCGA cell cohorts, INPP5E mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5E-associated genes across cancer lineages are ZIC3, TMEM244, and PNLIPRP3. Each is linked with INPP5E in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5E-to-partner and partner-to-INPP5E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC3 grouped by INPP5E-low versus INPP5E-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5E→partner) and Y-score (partner→INPP5E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TMEM244 →	+0.354	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.016	+4.551	<.001	.004	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.662	+3.307	<.001	.003	3	1
LARGE_INTESTINE	HOXA1 →	-1.068	-3.278	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

ZIC3 by INPP5E expression — BLOOD_Leukemia

Explore this box plot interactively →