INPP5D

Across TCGA pan-cancer cohorts, INPP5D mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated INPP5D data layer compared with 20 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher INPP5D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP5D expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where INPP5D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.826	1.000	.023	12	view →
LUAD	DFS	Quartile	All	0.808	0.435	.001	10	view →
HNSC	DFS	Median	All	0.909	0.994	.005	5	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

INPP5D–COAD (DFS)

Open the COAD breakdown →