INPP5D

Across TCGA pan-cancer cohorts, INPP5D RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of INPP5D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where INPP5D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INPP5D is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where INPP5D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP5D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.670	<.001	12	view →
COAD	All	IV	+1.548	<.001	11	view →
LUSC	Male	II,III,IV	−1.430	<.001	7	view →
STAD	All	II,III,IV	+1.389	<.001	7	view →
THCA	All	III,IV	+0.845	.004	7	view →
BRCA	Female	II,III,IV	−0.609	<.001	6	view →
KIRP	All	All	+0.817	<.001	5	view →
KICH	Male	II,III,IV	−0.822	.026	3	view →
READ	Female	All	+1.767	<.001	2	view →
UCEC	All	All	−1.281	<.001	2	view →
PRAD	All	All	−0.821	<.001	2	view →
LIHC	Female	II,III,IV	+0.745	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

INPP5D–KIRC

Open the KIRC breakdown →