INPP5D

Across TCGA patient cohorts, INPP5D mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. COAD shows the largest number of these associations.

The most reproducible INPP5D-associated genes across cancer lineages are mTOR_pS2448, ATM, and INPP4B. Each is linked with INPP5D in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP5D-to-partner and partner-to-INPP5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by INPP5D-low versus INPP5D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5D→partner) and Y-score (partner→INPP5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.095	-1.565	.042	.017	3	3
COAD	ATM →	-0.766	-3.000	<.001	.034	3	3
COAD	INPP4B →	-0.566	-3.313	.001	.010	3	3
COAD	PAI-1 →	+1.365	+3.330	<.001	.005	3	3
COAD	Dvl3 →	-0.454	-3.313	<.001	.010	3	3
UCEC	ERK2 →	+0.162	+1.925	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

mTOR_pS2448 by INPP5D expression — UCEC

Explore this box plot interactively →