INPP5D

Across TCGA cell cohorts, INPP5D mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5D-associated genes across cancer lineages are ZNF454, LMX1A, and LCN6. Each is linked with INPP5D in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5D-to-partner and partner-to-INPP5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF454 grouped by INPP5D-low versus INPP5D-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5D→partner) and Y-score (partner→INPP5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF454 →	+0.053	+3.777	<.001	.005	3	2
BLOOD_Myeloma	LMX1A →	+0.014	+3.906	<.001	.009	3	1
BLOOD_Myeloma	LCN6 →	+0.035	+3.906	.001	.009	3	1
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	1
URINARY_TRACT	SIRPD →	+0.187	+3.584	.003	.008	3	1
URINARY_TRACT	NXF5 →	+0.033	+4.321	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

ZNF454 by INPP5D expression — URINARY_TRACT

Explore this box plot interactively →