INPP4B

Across TCGA pan-cancer cohorts, INPP4B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP4B data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher INPP4B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP4B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where INPP4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
CCRCC	DFS	Tertile	IV	0.137	0.794	.024	7	view →
LSCC	DFS	Median	All	0.894	0.976	.026	3	view →
HNSC	OS	Quartile	All	0.932	0.852	.048	1	view →
LUAD	OS	Median	All	0.667	0.849	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INPP4B–PDAC (DFS)

Open the PDAC breakdown →