INPP4B

Across TCGA patient cohorts, INPP4B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP4B-associated genes across cancer lineages are JNK2, p21, and p38-MAPK_pT180_Y182. Each is linked with INPP4B in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP4B-to-partner and partner-to-INPP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by INPP4B-low versus INPP4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP4B→partner) and Y-score (partner→INPP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.229	+2.000	<.001	<.001	3	2
UCEC	p21 →	+0.139	+1.906	.026	.015	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.420	-2.087	.003	.005	3	2
UCEC	PCNA →	+0.193	+2.222	.005	.009	3	2
UCEC	ATM →	-0.447	-1.765	.002	.013	3	2
UCEC	Chk2_pT68 →	-0.137	-2.558	.023	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

JNK2 by INPP4B expression — UCEC

Explore this box plot interactively →