INPP4A

Across TCGA pan-cancer cohorts, INPP4A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INPP4A data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher INPP4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INPP4A expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where INPP4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.451	1.000	.016	13	view →
PDAC	OS	Median	All	0.443	0.309	.034	8	view →
HNSC	DFS	Median	II,III,IV	0.553	0.766	.010	8	view →
GBM	DFS	Tertile	All	0.896	0.661	.014	4	view →
LUAD	DFS	Tertile	All	0.957	0.871	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INPP4A–CCRCC (OS)

Open the CCRCC breakdown →