INPP4A

Across TCGA cell cohorts, INPP4A mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP4A-associated genes across cancer lineages are MMP26, RPP40, and CABP2. Each is linked with INPP4A in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP4A-to-partner and partner-to-INPP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by INPP4A-low versus INPP4A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP4A→partner) and Y-score (partner→INPP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.011	+3.700	<.001	.009	3	2
LARGE_INTESTINE	RPP40 →	+0.738	+3.451	<.001	.002	3	2
SKIN	CABP2 →	+0.021	+3.700	<.001	.009	3	1
SKIN	TMEM150B →	+0.181	+3.115	<.001	.004	3	1
SKIN	KRTAP13-1 →	+0.018	+3.700	<.001	.009	3	1
BLOOD_Lymphoma	OR56A1 →	+0.030	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

MMP26 by INPP4A expression — SKIN

Explore this box plot interactively →