INO80

Across TCGA pan-cancer cohorts, INO80 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INO80 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher INO80 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated INO80 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where INO80 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.368	0.696	<.001	35	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	14	view →
LSCC	OS	Tertile	All	0.947	0.729	.004	11	view →
HNSC	OS	Tertile	IV	0.942	0.730	.009	6	view →
LUAD	OS	Median	II,III,IV	0.467	0.907	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INO80–PDAC (OS)

Open the PDAC breakdown →