INO80

Across TCGA pan-cancer cohorts, INO80 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of INO80’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where INO80 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INO80 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where INO80 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INO80 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.648	<.001	10	view →
THCA	All	II,III,IV	−0.498	<.001	9	view →
LIHC	Female	II,III,IV	+0.958	<.001	7	view →
STAD	Male	II,III,IV	+1.053	<.001	6	view →
LUAD	All	All	−0.396	<.001	6	view →
CHOL	All	All	+2.001	<.001	5	view →
LUSC	All	All	−0.276	.001	4	view →
KICH	All	All	−0.432	.003	3	view →
KIRC	All	All	+0.260	.002	3	view →
UCEC	All	All	−0.562	.001	2	view →
BRCA	Female	All	−0.132	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

INO80–HNSC

Open the HNSC breakdown →