INO80

Across TCGA patient cohorts, INO80 mutation is significantly associated with the RNA expression of many other genes, with 5,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INO80-associated genes across cancer lineages are CKS2, CENPO, and KIF22. Each is linked with INO80 in more than 3 cancer types. Because this analysis shows association rather than direction, both INO80-to-partner and partner-to-INO80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS2 grouped by INO80-low versus INO80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INO80→partner) and Y-score (partner→INO80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKS2 →	+0.630	+1.678	<.001	<.001	3	4
UCEC	CENPO →	+0.448	+2.032	<.001	.001	3	4
SKCM	KIF22 →	+0.360	+2.434	.005	.001	3	4
UCEC	MTFMT →	+0.408	+1.874	<.001	<.001	3	3
UCEC	RPAP1 →	+0.444	+2.402	<.001	<.001	3	3
UCEC	OIP5 →	+0.767	+1.895	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,187 associations by consensus.

CKS2 by INO80 expression — UCEC

Explore this box plot interactively →