INO80

Across TCGA cell cohorts, INO80 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,741 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INO80-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Formation of cytoplasmic translation initiation complex, and Regulation of translation at postsynapse, modulating synaptic transmission. Each is linked with INO80 in more than 16 cancer types. Because this analysis shows association rather than direction, both INO80-to-partner and partner-to-INO80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by INO80-low versus INO80-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INO80→partner) and Y-score (partner→INO80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.099	+0.819	.001	<.001	3	17
PANCREAS	Formation of cytoplasmic translation initiation complex →	+0.106	+0.647	<.001	<.001	3	17
BLOOD_Leukemia	Regulation of translation at postsynapse, modulating synaptic transmission →	+0.126	+0.724	<.001	<.001	3	16
LARGE_INTESTINE	Nuclear export →	+0.099	+1.094	<.001	<.001	3	16
BONE	Positive regulation of nuclear cell cycle DNA replication →	+0.182	+0.871	<.001	<.001	3	16
BONE	RNA export from nucleus →	+0.116	+0.534	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,741 associations by consensus.

Viral translational termination-reinitiation by INO80 expression — UPPER_AERODIGESTIVE_TRACT

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