INMT

Across TCGA pan-cancer cohorts, INMT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated INMT data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher INMT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated INMT expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

GBM, CCRCC, and PDAC are the cancer types where INMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.666	0.990	.001	12	view →
CCRCC	DFS	Tertile	All	1.000	0.167	.010	12	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
LUAD	OS	Median	All	1.000	0.830	.031	2	view →
HNSC	DFS	Median	IV	1.000	0.637	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

INMT–GBM (DFS)

Open the GBM breakdown →