INMT

Across TCGA cell cohorts, INMT RNA expression is significantly associated with the go_rna of many other GO terms, with 901 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible INMT-associated GO terms across cancer lineages are Regulation of intrinsic apoptotic signaling pathway, Post-translational protein targeting to membrane, translocation, and Regulation of intracellular transport. Each is linked with INMT in more than 5 cancer types. Because this analysis shows association rather than direction, both INMT-to-partner and partner-to-INMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intrinsic apoptotic signaling pathway grouped by INMT-low versus INMT-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INMT→partner) and Y-score (partner→INMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of intrinsic apoptotic signaling pathway →	+0.080	+0.119	<.001	.005	3	6
SKIN	Post-translational protein targeting to membrane, translocation →	+0.052	+1.118	.002	.001	3	5
SKIN	Regulation of intracellular transport →	+0.046	+0.880	<.001	.009	3	5
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.067	+1.206	<.001	<.001	3	5
BLOOD_Leukemia	Regulation of myoblast fusion →	+0.048	+0.067	.002	<.001	3	5
SKIN	Amyloid-beta clearance by transcytosis →	+0.086	+0.834	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 901 associations by consensus.

Regulation of intrinsic apoptotic signaling pathway by INMT expression — OESOPHAGUS

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