INMT

Across TCGA cell cohorts, INMT mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INMT-associated genes across cancer lineages are IAPP, FCN2, and MOB1B. Each is linked with INMT in more than 1 cancer types. Because this analysis shows association rather than direction, both INMT-to-partner and partner-to-INMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAPP grouped by INMT-low versus INMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INMT→partner) and Y-score (partner→INMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IAPP →	+0.331	+2.643	<.001	.007	3	1
LARGE_INTESTINE	FCN2 →	+0.022	+3.415	<.001	.001	3	1
LARGE_INTESTINE	MOB1B →	+0.783	+3.131	.001	.008	3	1
LARGE_INTESTINE	FAM180A →	+0.149	+3.531	<.001	.007	3	1
LARGE_INTESTINE	GYPE →	+0.015	+2.556	<.001	.006	3	1
LARGE_INTESTINE	LY6G6F →	+0.108	+2.560	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

IAPP by INMT expression — LARGE_INTESTINE

Explore this box plot interactively →