INMT

Across TCGA cell cohorts, INMT mutation is significantly associated with the mutation status of many other genes, with 1,664 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INMT-associated genes across cancer lineages are TRIP11, C2orf42, and TCF25. Each is linked with INMT in more than 2 cancer types. Because this analysis shows association rather than direction, both INMT-to-partner and partner-to-INMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIP11 grouped by INMT-low versus INMT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INMT→partner) and Y-score (partner→INMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRIP11 →	+4.239	+5.053	.007	.007	1	3
SKIN	C2orf42 →	+4.824	+5.392	.004	.004	1	3
SKIN	TCF25 →	+4.824	+5.392	.004	.004	1	3
SKIN	SYNPO2L →	+4.824	+5.392	.004	.004	1	3
SKIN	SH2B1 →	+5.824	+5.824	.002	.002	1	3
BLOOD_Leukemia	ELP2 →	+4.736	+5.560	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,664 associations by consensus.

TRIP11 by INMT expression — SKIN

Explore this box plot interactively →