INMT-MINDY4

Across TCGA pan-cancer cohorts, INMT-MINDY4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated INMT-MINDY4 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher INMT-MINDY4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INMT-MINDY4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CHOL show a favorable association.

DLBC, UCEC, and KIRP are the cancer types where INMT-MINDY4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	63	view →
UCEC	OS	Tertile	IV	0.280	0.789	<.001	42	view →
KIRP	OS	Quartile	All	0.865	0.953	.008	40	view →
LUAD	OS	Quartile	All	0.784	0.616	<.001	34	view →
CHOL	OS	Median	All	0.825	0.403	.002	21	view →
MESO	DFS	Median	IV	0.558	0.202	.003	21	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.792	.016	20	view →
KIRC	OS	Tertile	All	0.703	0.561	.013	19	view →
STAD	DFS	Median	All	0.465	0.620	.002	17	view →
LGG	OS	Tertile	All	0.647	0.856	.001	15	view →
SARC	OS	Tertile	All	0.926	0.765	.011	12	view →
PRAD	DFS	Tertile	All	0.866	0.735	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

INMT-MINDY4–DLBC (OS)

Open the DLBC breakdown →