INMT-MINDY4

Across TCGA pan-cancer cohorts, INMT-MINDY4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of INMT-MINDY4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where INMT-MINDY4 RNA is repressed in tumor relative to normal tissue. In most cancer types INMT-MINDY4 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and LUSC are the cancer types where INMT-MINDY4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INMT-MINDY4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.648	<.001	8	view →
BLCA	All	All	−0.118	<.001	8	view →
LUSC	Female	II,III,IV	−0.985	<.001	7	view →
KICH	All	All	−0.077	<.001	7	view →
UCEC	All	All	−0.173	<.001	6	view →
BRCA	All	III,IV	−0.087	<.001	6	view →
KIRC	All	II,III,IV	−0.052	.003	6	view →
STAD	All	All	−0.264	<.001	3	view →
PRAD	All	All	−0.258	<.001	2	view →
KIRP	All	All	−0.049	<.001	2	view →
LIHC	Male	All	−0.031	.021	2	view →
COAD	Male	II,III,IV	−0.025	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

INMT-MINDY4–LUAD

Open the LUAD breakdown →