INHBB

Across TCGA patient cohorts, INHBB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INHBB-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and JNK2. Each is linked with INHBB in more than 1 cancer types. Because this analysis shows association rather than direction, both INHBB-to-partner and partner-to-INHBB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by INHBB-low versus INHBB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INHBB→partner) and Y-score (partner→INHBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.227	-2.115	.038	.019	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.807	.035	.003	3	1
UCEC	JNK2 →	+0.235	+3.196	.006	.009	3	1
UCEC	MEK1 →	+0.346	+3.459	.030	.005	3	1
UCEC	p62 Lck ligand →	+0.390	+2.115	.006	.019	3	1
UCEC	P-Cadherin →	-0.144	-3.311	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-8 by INHBB expression — UCEC

Explore this box plot interactively →