INCENP

Across TCGA patient cohorts, INCENP mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INCENP-associated genes across cancer lineages are Bad_pS112, MEK1, and PRDX1. Each is linked with INCENP in more than 2 cancer types. Because this analysis shows association rather than direction, both INCENP-to-partner and partner-to-INCENP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by INCENP-low versus INCENP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INCENP→partner) and Y-score (partner→INCENP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bad_pS112 →	-0.149	-2.986	.037	.035	3	3
UCEC	MEK1 →	+0.425	+2.906	.002	.001	3	2
UCEC	PRDX1 →	+0.178	+1.807	.024	.025	3	2
UCEC	ATM →	-0.551	-2.687	.001	.005	3	2
UCEC	4E-BP1 →	+0.303	+1.614	.003	.041	3	2
SKCM	Smac →	+0.413	+2.824	.011	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Bad_pS112 by INCENP expression — UCEC

Explore this box plot interactively →