INCENP

Across TCGA pan-cancer cohorts, INCENP RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated INCENP data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher INCENP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated INCENP expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

MESO, KICH, and ACC are the cancer types where INCENP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.382	0.669	<.001	102	view →
KICH	OS	Quartile	All	0.517	1.000	<.001	84	view →
ACC	DFS	Median	All	0.407	0.753	<.001	78	view →
PAAD	DFS	Median	All	0.176	0.372	<.001	60	view →
LIHC	OS	Median	All	0.698	0.848	<.001	58	view →
UCS	DFS	Median	IV	0.952	0.367	.001	54	view →
LUAD	OS	Median	All	0.280	0.424	<.001	47	view →
KIRC	DFS	Median	All	0.732	0.522	.003	43	view →
BLCA	DFS	Quartile	II,III,IV	0.392	0.555	.002	34	view →
LGG	OS	Tertile	All	0.723	0.864	<.001	31	view →
KIRP	OS	Tertile	All	0.543	0.775	.022	25	view →
SKCM	OS	Tertile	All	0.294	0.421	.014	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

INCENP–MESO (OS)

Open the MESO breakdown →