IMPDH2

Across TCGA patient cohorts, IMPDH2 mutation is significantly associated with the RNA expression of many other genes, with 777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPDH2-associated genes across cancer lineages are LINC00508, SNORD105B, and OR5B17. Each is linked with IMPDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPDH2-to-partner and partner-to-IMPDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00508 grouped by IMPDH2-low versus IMPDH2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH2→partner) and Y-score (partner→IMPDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC00508 →	+1.001	+3.549	<.001	.002	3	2
SKCM	SNORD105B →	+0.587	+4.913	<.001	.002	3	2
BLCA	OR5B17 →	+0.024	+4.718	<.001	.003	3	2
SKCM	RNU6-192P →	+0.344	+6.219	<.001	<.001	3	2
UCEC	RN7SKP60 →	+0.189	+2.350	<.001	.005	3	2
COAD	RN7SL488P →	+0.231	+4.374	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 777 associations by consensus.

LINC00508 by IMPDH2 expression — BLCA

Explore this box plot interactively →