IMPDH1P4

Across TCGA patient cohorts, IMPDH1P4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPDH1P4-associated genes across cancer lineages are RPS20P25, CYCSP26, and OR6M2P. Each is linked with IMPDH1P4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPDH1P4-to-partner and partner-to-IMPDH1P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS20P25 grouped by IMPDH1P4-low versus IMPDH1P4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1P4→partner) and Y-score (partner→IMPDH1P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS20P25 →	+0.296	+5.081	<.001	.008	3	1
UCEC	CYCSP26 →	+0.325	+5.299	<.001	.006	3	1
UCEC	OR6M2P →	+0.199	+5.081	.004	.008	3	1
UCEC	AGGF1P9 →	+0.211	+5.551	<.001	.004	3	1
UCEC	NUTF2P8 →	+0.291	+4.982	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RPS20P25 by IMPDH1P4 expression — UCEC

Explore this box plot interactively →