IMPDH1P4

Across TCGA pan-cancer cohorts, IMPDH1P4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IMPDH1P4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IMPDH1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IMPDH1P4 is over-expressed in tumor.

HNSC, KICH, and BRCA are the cancer types where IMPDH1P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IMPDH1P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.027	.005	7	view →
KICH	Female	III,IV	+0.033	<.001	5	view →
BRCA	Female	All	+0.023	.024	4	view →
ESCA	All	All	+0.053	.028	2	view →
PRAD	All	All	+0.018	.024	2	view →
LUSC	Male	All	+0.011	.017	2	view →
COAD	All	II,III,IV	+0.067	.047	1	view →
LUAD	All	All	+0.042	.027	1	view →
LIHC	Male	All	+0.013	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IMPDH1P4–HNSC

Open the HNSC breakdown →