IMPDH1

Across TCGA patient cohorts, IMPDH1 mutation is significantly associated with the RNA expression of many other genes, with 1,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPDH1-associated genes across cancer lineages are SLC25A1P4, IGFL1P2, and MIR3651. Each is linked with IMPDH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IMPDH1-to-partner and partner-to-IMPDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A1P4 grouped by IMPDH1-low versus IMPDH1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPDH1→partner) and Y-score (partner→IMPDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SLC25A1P4 →	+0.130	+4.601	<.001	.004	3	3
BRCA	IGFL1P2 →	+0.328	+4.540	<.001	.009	3	2
UCEC	MIR3651 →	+0.299	+1.496	.006	.007	3	2
CESC	H3P18 →	+1.319	+4.539	<.001	.008	3	2
CESC	NEK2P2 →	+0.055	+4.539	<.001	.008	3	2
LUSC	TUBAP4 →	+0.135	+3.577	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,091 associations by consensus.

SLC25A1P4 by IMPDH1 expression — CESC

Explore this box plot interactively →