IMPACT

Across TCGA patient cohorts, IMPACT mutation is significantly associated with the RNA expression of many other genes, with 867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IMPACT-associated genes across cancer lineages are MIR6803, RN7SKP214, and LINC01029. Each is linked with IMPACT in more than 1 cancer types. Because this analysis shows association rather than direction, both IMPACT-to-partner and partner-to-IMPACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by IMPACT-low versus IMPACT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPACT→partner) and Y-score (partner→IMPACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.197	+4.893	<.001	.001	3	2
UCEC	RN7SKP214 →	+0.313	+2.749	<.001	<.001	3	2
COAD	LINC01029 →	+0.276	+4.543	<.001	.005	3	2
COAD	MIR3135A →	+0.882	+4.602	<.001	.008	3	2
UCEC	RPL36P19 →	+0.116	+2.811	<.001	.004	3	2
SKCM	RNU5A-4P →	+0.372	+3.669	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 867 associations by consensus.

MIR6803 by IMPACT expression — UCEC

Explore this box plot interactively →