IMPA1

Across TCGA patient cohorts, IMPA1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,676 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IMPA1-associated genes across cancer lineages are TTK, LMNB1, and TCF19. Each is linked with IMPA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IMPA1-to-partner and partner-to-IMPA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IMPA1 versus TTK in GBM, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA1→partner) and Y-score (partner→IMPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTK →	-1.183	-0.350	<.001	.003	3	5
GBM	LMNB1 →	-1.221	-0.473	<.001	<.001	3	5
GBM	TCF19 →	-0.647	-0.360	<.001	<.001	3	5
GBM	CCNA2 →	-1.079	-0.421	<.001	<.001	3	5
HNSC	H2BC15 →	-0.672	-0.253	.001	<.001	3	5
GBM	CDC6 →	-1.007	-0.467	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,676 associations by consensus.

IMPA1 vs TTK — GBM

Explore this scatter interactively →