IMP3

Across TCGA cell cohorts, IMP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,336 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IMP3-associated GO terms across cancer lineages are Enzyme-directed rRNA pseudouridine synthesis, rRNA pseudouridine synthesis, and DNA replication proofreading. Each is linked with IMP3 in more than 17 cancer types. Because this analysis shows association rather than direction, both IMP3-to-partner and partner-to-IMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Enzyme-directed rRNA pseudouridine synthesis grouped by IMP3-low versus IMP3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IMP3→partner) and Y-score (partner→IMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Enzyme-directed rRNA pseudouridine synthesis →	+0.133	+0.949	<.001	<.001	3	18
BONE	rRNA pseudouridine synthesis →	+0.113	+0.730	<.001	<.001	3	15
BONE	DNA replication proofreading →	+0.191	+0.712	.007	.003	3	14
BLOOD_Lymphoma	Maturation of 5.8S rRNA →	+0.084	+0.743	<.001	<.001	3	14
BLOOD_Lymphoma	Mitochondrial ribosome assembly →	+0.094	+0.838	<.001	<.001	3	14
BLOOD_Myeloma	Ribosome assembly →	+0.105	+0.915	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,336 associations by consensus.

Enzyme-directed rRNA pseudouridine synthesis by IMP3 expression — SOFT_TISSUE

Explore this box plot interactively →